Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 20ul Deep Well Plates For more information on UNC5

For more information on UNC5 proteins

Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres

This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors

Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 20ul Deep Well Plates For more information on UNC5Alpha chains of type IV collagen have a non collagenous domain (NC1) at their C terminus frequent interruptions of the G X Y repeats in the long central triple helical domain (which may cause flexibility in the triple helix) and a short N terminal triple helical 7S domain. Type IV collagen is the major structural component of glomerular basement membranes (GBM) forming a 'chicken wire' meshwork together with laminins proteoglycans and entactin