Clock Monoclonal Antibody, 100ul Vortex Mixer DUF1220 copy number variations in

DUF1220 copy number variations in human chromosomal region 1q21

The encoded protein recognizes an octamer sequence in the DNA of target genes

DLG4 and AIP1

The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II

Clock Monoclonal Antibody, 100ul Vortex Mixer DUF1220 copy number variations inThe protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix loop helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes.