GDF8 Polyclonal Antibody, 100ul ADME head and neck cancers

head and neck cancers

Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene

Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia

Its specific function has not been determined

GDF8 Polyclonal Antibody, 100ul ADME head and neck cancersThis gene encodes a secreted ligand of the TGF beta (transforming growth factor beta) superfamily of proteins. Ligands of this family bind various TGF beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide linked homodimer. This protein negatively regulates skeletal muscle cell proliferation