Trk B Polyclonal Antibody, 100ul[BT-AP09214] Cell Transfection channelopathy-associated insensitivity to pain

channelopathy-associated insensitivity to pain

Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior

extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes

but the biological validity of only one transcript has been determined

Trk B Polyclonal Antibody, 100ul[BT-AP09214] Cell Transfection channelopathy-associated insensitivity to painNTRK2 encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in NTRK2 have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.