Angiomotin-L1 Polyclonal Antibody, 100ul Shaker&Mixing Some of the isoforms contain

Some of the isoforms contain regions of similarity to beta-defensins| a family of antimicrobial peptides

activation

a heterotrimeric molecule

Mutations in this gene cause nephronophthisis (NPHP)| an autosomal recessive kidney disease characterized by tubular basement membrane disruption| interstitial lymphohistiocytic cell infiltration| and development of cysts at the corticomedullary border of the kidneys

Angiomotin-L1 Polyclonal Antibody, 100ul Shaker&Mixing Some of the isoforms containAngiomotin like protein 1 encoded by AMOTL1 is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene.