Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter Multiple alternatively spliced variants

Multiple alternatively spliced variants

MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes

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CHRNA1 encodes an alpha subunit that plays a role in acetlycholine binding/channel gating

Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter Multiple alternatively spliced variantsMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.