Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks consisting of a 110 kD

consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55

subcellular location:Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN

May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A

is amplified in the mouse transformed 3T3 cell line

Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks consisting of a 110 kDThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.