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Bcl-2 Polyclonal Antibody, 50ul[BT-AP00857] Virus Packaging but is upregulated upon activation

SKU: 79825635079

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Bcl-2 Polyclonal Antibody, 50ul[BT-AP00857] Virus Packaging but is upregulated upon activationBCL2 encodes an integral outer mitochondrial membrane protein (BCL2, apoptosis regulator) that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

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Description

but is upregulated upon activation of lymphocytes

This encoded protein is expressed on Natural killer (NK)

A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1)| and binds to alpha- and beta-dystrobrevins| which are components of the dystrophin-associated protein complex (DPC)

This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs

Bcl-2 Polyclonal Antibody, 50ul[BT-AP00857] Virus Packaging but is upregulated upon activationBCL2 encodes an integral outer mitochondrial membrane protein (BCL2, apoptosis regulator) that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

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