PARP-4 Polyclonal Antibody, 100ul Thermo Mix Defects in SIX1 are a

Defects in SIX1 are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3)

The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes

This protein forms a receptor complex with interleukine 10 receptor

Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum

PARP-4 Polyclonal Antibody, 100ul Thermo Mix Defects in SIX1 are aPARP4 encodes poly(ADP ribosyl)transferase like 1 protein, which is capable of catalyzing a poly(ADP ribosyl)ation reaction. Poly [ADP ribose] polymerase 4 has a catalytic domain which is homologous to that of poly (ADP ribosyl) transferase, but lacks an N terminal DNA binding domain which activates the C terminal catalytic domain of poly (ADP ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may