JAZF1 Rabbit Polyclonal Antibody, 50ul Dry Bath The LIM and SH3 protein

The LIM and SH3 protein 1 is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane

The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors

653 bases and maps to human chromosome 2q14

It encodes an RNA-binding protein that is important for spermatogenesis

JAZF1 Rabbit Polyclonal Antibody, 50ul Dry Bath The LIM and SH3 proteinThis gene encodes a nuclear protein with three C2H2 type zinc fingers and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however not all variants have been fully characterized