HECW1 Polyclonal Antibody, 100ul Pipette Micro Tips PPP1R15B encodes a protein phosphatase

PPP1R15B encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC)

The cytokine function is exclusively attributed to the secreted C-terminal peptide

a process which occurs normally during development but also during metastasis

HECW1 Polyclonal Antibody, 100ul Pipette Micro Tips PPP1R15B encodes a protein phosphataseE3 ubiquitin protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway: Protein modification; protein ubiquitination.,Contains 1 C2 domain.,Contains 1 HECT (E6AP type E3 ubiquitin protein ligase) domain.,Contains 2 WW