Phospho-Btk (Y551) Polyclonal Antibody, 50ul sgRNA Library Construction Two other isoforms of intracellular
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Phospho-Btk (Y551) Polyclonal Antibody, 50ul sgRNA Library Construction Two other isoforms of intracellularBruton tyrosine kinase encoded by BTK plays a crucial role in B cell development. Mutations in BTK cause X linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
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