Human Interleukin-10 Receptor Subunit Alpha, IL10RA ELISA Kit, 96T Filtration Take bold action with the

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May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function

This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs

These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents

Human Interleukin-10 Receptor Subunit Alpha, IL10RA ELISA Kit, 96T Filtration Take bold action with theCell surface receptor for the cytokine IL10 that participates in IL10 mediated anti inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed: 16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively