Raf-1(Phospho Ser338) Polyclonal Antibody, 20ul Sampling Tubes myotrophic lateral sclerosis 2 chromosomal

myotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein contains a calcium-dependent membrane targeting C2 domain

When formed into complexes| these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane

Defects in this gene can lead to the calcification of joints and arteries

it is expressed in frontal lobe

Raf-1(Phospho Ser338) Polyclonal Antibody, 20ul Sampling Tubes myotrophic lateral sclerosis 2 chromosomalThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.