Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation The composition of the APC

The composition of the APC is highly conserved in organisms from yeast to humans

Members of the Ikaros (ZNFN1A1

This gene encodes a member of the G-protein coupled receptor family

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules

Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation The composition of the APCAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.