mGluR-4 Polyclonal Antibody, 50ul Cell Dissociation Three transcript variants encoding two

Three transcript variants encoding two distinct isoforms have been identified for this gene

Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2)

and stimulate DNA recombination

The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex

mGluR-4 Polyclonal Antibody, 50ul Cell Dissociation Three transcript variants encoding twoL glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative