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IGF-IR Monoclonal Antibody, 100ul[BT-MCA0099] Culture Media cofactor:Binds 1 Fe(3+) ion per
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IGF-IR Monoclonal Antibody, 100ul[BT-MCA0099] Culture Media cofactor:Binds 1 Fe(3+) ion perThis receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have
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