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CD11b Polyclonal Antibody, 50ul[BT-AP14795] Adenovirus Packaging Mutations in this gene underlie

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CD11b Polyclonal Antibody, 50ul[BT-AP14795] Adenovirus Packaging Mutations in this gene underlieThis gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte specific integrin referred to as macrophage receptor 1 ('Mac 1'), or inactivated C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to

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Description

Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome| Donohue syndrome and Rabson-Mendenhall syndrome

It can inhibit rosette formation and interacts with heparin

It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides

such as cAMP responsive element binding protein (CREB) and MYC

CD11b Polyclonal Antibody, 50ul[BT-AP14795] Adenovirus Packaging Mutations in this gene underlieThis gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte specific integrin referred to as macrophage receptor 1 ('Mac 1'), or inactivated C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to

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