TPH2 Polyclonal Antibody, 100ul Peptide Modification This gene is localized to

This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers

A pseudogene of MED21 is located on chromosome 8

the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity

The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein

TPH2 Polyclonal Antibody, 100ul Peptide Modification This gene is localized toTPH2 encodes a member of the pterin dependent aromatic acid hydroxylase family. The tryptophan hydroxylase 2 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.