Mouse DNA-dependent Protein Kinase Catalytic Subunit, PRKDC ELISA Kit , 96T Molecular Sciences The message for this gene

The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney

Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression

also called juvenile hemochromatosis (JH)

The protein kinase encoded by CDK11A can be cleaved by caspases and may play a role in cell apoptosis

Mouse DNA-dependent Protein Kinase Catalytic Subunit, PRKDC ELISA Kit , 96T Molecular Sciences The message for this geneSerine threonine protein kinase that acts as a molecular sensor for DNA damage (By similarity). Involved in DNA non homologous end joining (NHEJ) required for double strand break (DSB) repair and V(D)J recombination (By similarity). Must be bound to DNA to express its catalytic properties (By similarity). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (By similarity).