MCF2 Polyclonal Antibody, 20ul NGS Oligos Mutations in this gene result

Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy

Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways

The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2

The encoded transmembrane protein forms interchain disulfide bonds with SCN2A

MCF2 Polyclonal Antibody, 20ul NGS Oligos Mutations in this gene resultThe oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.