Tie-1 Polyclonal Antibody, 50ul Centrifuges Alternativley spliced transcript variants encoding

Alternativley spliced transcript variants encoding different isoforms have been identified in this gene

This gene is a candidate for the ovarian tumor suppressor gene

Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus| multiple sclerosis and rheumatoid arthritis

Alternatively spliced transcript variants have been described for PDE10A

Tie-1 Polyclonal Antibody, 50ul Centrifuges Alternativley spliced transcript variants encodingTIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth