FoxO3A(Phospho Ser253) Polyclonal Antibody, 50ul Liquid Handling ＆Storage a rare and lethal autosomal

a rare and lethal autosomal recessive disorder of early childhood

The encoded protein has been shown to control the cellular level of FBXL7| a protein that induces mitotic arrest| by targeting it for polyubiquitylation and proteasomal degradation

which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits

It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS

FoxO3A(Phospho Ser253) Polyclonal Antibody, 50ul Liquid Handling ＆Storage a rare and lethal autosomalThis gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.