Tcl1 Polyclonal Antibody, 50ul Peripheral Blood Separation Tube KNG1 uses alternative splicing to

KNG1 uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK)

Isoform 3 does not mediate any activation

Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits

This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex

Tcl1 Polyclonal Antibody, 50ul Peripheral Blood Separation Tube KNG1 uses alternative splicing toOverexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T cell antigen receptor (TCR) alpha (MIM 186880) or TCR beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998