CNDD3 Polyclonal Antibody, 100ul Roller Bottles |disease:Defects in KLKB1 are the

|disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency)

The encoded protein is associated with the nuclear scaffold in proliferating cells| and binds to actin and the catalytic subunit of protein phosphatase-1| suggesting that it functions as a regulatory subunit of protein phosphatase-1

GDP and GMP

The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma

CNDD3 Polyclonal Antibody, 100ul Roller Bottles |disease:Defects in KLKB1 are theCondensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non SMC subunits. NCAPD3 is 1 of 3 non SMC subunits that define condensin II (Ono et al., 2003