Raf-1 Polyclonal Antibody, 50ul[BT-AP13537] Custom Peptide Synthesis Mutation of this motif results

Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens

it is highly conserved among species

It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity

GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles

Raf-1 Polyclonal Antibody, 50ul[BT-AP13537] Custom Peptide Synthesis Mutation of this motif resultsThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.