Vav3 Polyclonal Antibody, 100ul ROS/Nitric Oxide Detection SP100 (SP100 nuclear antigen) encodes

SP100 (SP100 nuclear antigen) encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC)

Alternative splicing and alternative promoter usage results in multiple transcript variants

and proteolysis

Vav3 Polyclonal Antibody, 100ul ROS/Nitric Oxide Detection SP100 (SP100 nuclear antigen) encodesVAV3 is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide free states of these GTPases. Alternatively spliced transcript variants encoding