SUV91 Polyclonal Antibody, 100ul Lysosome Mutations in this gene and

Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease

The protein is also a component of mammalian CORVET

The protein encoded by this gene belongs to the Fbls class and| in addition to an F-box| contains several tandem leucine-rich repeats

Sec7 and coiled-coil domains) family

SUV91 Polyclonal Antibody, 100ul Lysosome Mutations in this gene andThis gene encodes an evolutionarily conserved protein containing an N terminal chromodomain and a C terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.