Raf-1(Phospho Ser301) Polyclonal Antibody, 20ul Recombinant Ab Production two (me2) or three (me3)

two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain

Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens

which facilitates cellular transformation

The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint

Raf-1(Phospho Ser301) Polyclonal Antibody, 20ul Recombinant Ab Production two (me2) or three (me3)This gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.