WIPI2 Rabbit Polyclonal Antibody, 50ul Biomatrix The large catalytic subunit has

The large catalytic subunit has four domains: domain I

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Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization| inositol triphosphate production and secretion of IL6 and CSF1

a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion

WIPI2 Rabbit Polyclonal Antibody, 50ul Biomatrix The large catalytic subunit hasWD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta propeller platform for simultaneous and reversible protein protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7 bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas Cezanne et al., 2004