TGR5 Polyclonal Antibody, 100ul Centrifugal Filter ADAMTS12 (ADAM metallopeptidase with thrombospondin

ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12) encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family

and contributes to the regulation of immune responses

This subunit is a receptor for the antiepileptic drug

The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking

TGR5 Polyclonal Antibody, 100ul Centrifugal Filter ADAMTS12 (ADAM metallopeptidase with thrombospondinGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.