GK921 Catalog No.:M8587-2 cells remain viable 1 week

cells remain viable 1 week post-treatment even at 10 μM of Nutlin-3

InChi: InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13

VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism

Molecular Weight: 460

GK921 Catalog No.:M8587-2 cells remain viable 1 weekGK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0. 905 M). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI 1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC. Product information CAS Number: