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TL 12-186 RD9 Degrader-1 The monoamine reuptake blocker brasofensine

SKU: 18756381221

4.5
EUR195.00 EUR225.00

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TL 12-186 RD9 Degrader-1 The monoamine reuptake blocker brasofensineTL12 186 is a multikinase degrading PROTAC. Product information CAS Number: 2250025 88 6 Molecular Weight: 931. 46 Formula: C44H51ClN10O9S Chemical Name: N (2 (2 (2 (4 (4 ((5 Chloro 4 ((2 (isopropylsulfonyl)phenyl)amino)pyrimidin 2 yl)amino)phenyl)piperazin 1 yl)ethoxy)ethoxy)ethyl) 2 ((2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxoisoindolin 4 yl)amino)acetamide Smiles:

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Description

The monoamine reuptake blocker brasofensine reverses akinesia without dyskinesia in MPTP-treated and levodopa-primed common marmosets

with virtually complete inhibition at 10 μM

5 nM (η-C1B)

Kobayashi M

TL 12-186 RD9 Degrader-1 The monoamine reuptake blocker brasofensineTL12 186 is a multikinase degrading PROTAC. Product information CAS Number: 2250025 88 6 Molecular Weight: 931. 46 Formula: C44H51ClN10O9S Chemical Name: N (2 (2 (2 (4 (4 ((5 Chloro 4 ((2 (isopropylsulfonyl)phenyl)amino)pyrimidin 2 yl)amino)phenyl)piperazin 1 yl)ethoxy)ethoxy)ethyl) 2 ((2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxoisoindolin 4 yl)amino)acetamide Smiles:

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