Vadimezan (DMXAA) lase 1038/s41598-020-58587-2

1038/s41598-020-58587-2

is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50 ~ 0

4-bis((S)-3-methylmorpholino)pyrido[2

and SNAI2 (Snail family zinc finger 1 and 2

Vadimezan (DMXAA) lase 1038/s41598-020-58587-2Vadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti tumor activity of tumor associated macrophages. Product information CAS Number: 117570 53 3 Molecular Weight: 282. 29