CCT128930 - CAS# 885499-61-6 iapine D8 fumarate Ann Surg Oncol

Ann Surg Oncol

Ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis

EC(50) = 490 nmol/L)

Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling

CCT128930 - CAS# 885499-61-6 iapine D8 fumarate Ann Surg OncolCCT128930 is a novel ATP competitive AKT inhibitor discovered using fragment and structure based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition.