ANA-12 Catalog No.:M8450-10 Magistretti PJ

Magistretti PJ

VU-0240551

An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity

Purvalanol A does not inhibit transcription under cell-free conditions

ANA-12 Catalog No.:M8450-10 Magistretti PJANA 12 is aTrkB receptor antagonist. ANA 12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Systemic administration of ANA 12 to adult mice decreased TrkB activity in the brain without affecting neuronal survival. Mice administered ANA 12 demonstrated reduced anxiety and depression related behaviors on a variety of tests predictive of anxiolytic and antidepressant