Azeliragon HCl - CAS# 1284150-65-7 66049 small-molecule inhibitors of WNT signaling

small-molecule inhibitors of WNT signaling from a cell-based pathway screen

is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0

Tempostatin

InChi: InChI=1S/C19H21NO2/c1-13(15-7-8-18-19(11-15)22-10-9-21-18)20-17-12-16(17)14-5-3-2-4-6-14/h2-8

Azeliragon HCl - CAS# 1284150-65-7 66049 small-molecule inhibitors of WNT signalingAzeliragon HCl, CAS No. 1284150 65 7, also known as TTP488 and PF 04494700, is a potent and orally active RAGE inhibitor. RAGE (receptor for advanced glycation endproducts) is a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's associated protein, into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon is a promising agent for for