WZ3146 Size:10mg solid 356559-20-1

356559-20-1

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

InChi: InChI=1S/C22H48N12O2/c23-17(5-1-7-31-21(25)26)19(35)29-9-3-11-33-13-15-34(16-14-33)12-4-10-30-20(36)18(24)6-2-8-32-22(27)28/h17-18H

PF-06447475 is well tolerated in rats

WZ3146 Size:10mg solid 356559-20-1WZ 3146 is a covalent or irreversible pyrimidine based EGFR inhibitor against EGFR T790M. WZ 3146 was identified by screening an irreversible kinase inhibitor library specifically against EGFR T790M. WZ 3146 potently suppresses the growth of EGFR T790M containing cell lines and inhibits EGFR phosphorylation. WZ 3146 is also effective in murine models of lung cancer driven by EGFR T790M. WZ 3146 may be clinically more effective and better tolerated