TAS-103 dihydrochloride l maleate CAS Number: 1449240-68-9

CAS Number: 1449240-68-9

combination treatment with Everolimus and trastuzumab significantly decreases the xenograft tumor size (410

It is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases

a third-generation

TAS-103 dihydrochloride l maleate CAS Number: 1449240-68-9TAS 103, also known as BMS 247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS 103 has been reported to be a potent topoisomerase II poison. TAS 103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0. 05). The combination with CDDP augmented the antitumor activity of TAS 103 (p<0. 05), indicating that CDDP is one of the most potent candidates