Istaroxime Hydrochloride Size:Solid 10 mg 8E)-N-(4-hydroxyphenyl)-3

8E)-N-(4-hydroxyphenyl)-3

is an inhibitor of ATP synthase

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

Smiles: C=CC1=CC(O)=CC2N=C(OC=21)C1=CC(F)=C(O)C=C1

Istaroxime Hydrochloride Size:Solid 10 mg 8E)-N-(4-hydroxyphenyl)-3Istaroxime, also known as PST 2744, is a positive inotropic agent that mediates its action through inhibition of sodium potassium adenosine triphosphatase (Na+ K+ ATPase). Na+ K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy