JW 55 nspiride Hydrochloride The in vitro metab
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JW 55 nspiride Hydrochloride The in vitro metabJW55 is a tankyrase 1 and tankyrase 2 (TNKS1 2) inhibitor. JW55 functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1 2), regulators of the catenin destruction complex. Inhibition of TNKS1 2 poly(ADP ribosyl)ation activity by JW55 led to stabilization of AXIN2, a member of the catenin destruction complex, followed by increased degradation of catenin. In a dose dependent manner, JW55 inhibited canonical Wnt signaling in
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