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CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0273 suggesting potentially a long-lasting effect

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CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0273 suggesting potentially a long-lasting effectCP 690550, CAS No. 477600 75 2, is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. It inhibits recombinant human JAK1 (IC50 ~ 3. 2 nM), JAK2 (IC50 ~4. 1 nM), and JAK3 (IC50 ~1. 6 nM). In cellular assays CP 690550 showed potent effects in the IL 2 blast proliferation assay (IC50 ~11 nM, mediated via JAK1 and JAK3) and HU03 cellular specificity assay (IC50 ~324 nM,

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suggesting potentially a long-lasting effect of S3I-201 on tumor growth

PRT4165 was used at 10-50 µM final concentration in various in vitro assays

Smiles: [K+]

a potent and selective inhibitor of polo-like kinase 1

CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0273 suggesting potentially a long-lasting effectCP 690550, CAS No. 477600 75 2, is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. It inhibits recombinant human JAK1 (IC50 ~ 3. 2 nM), JAK2 (IC50 ~4. 1 nM), and JAK3 (IC50 ~1. 6 nM). In cellular assays CP 690550 showed potent effects in the IL 2 blast proliferation assay (IC50 ~11 nM, mediated via JAK1 and JAK3) and HU03 cellular specificity assay (IC50 ~324 nM,

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