GRP-60367 - CAS# 1309241-34-6 072 Ogasawara K

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GRP-60367 - CAS# 1309241-34-6 072 Ogasawara KGRP 60367, CAS No. 1309241 34 6, is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP 60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell to cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a

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