WWL113 - Ces3 and Ces1f Inhibitor. CAS# 947669-86-5 075 exhibits more selective for inhibiting
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WWL113 - Ces3 and Ces1f Inhibitor. CAS# 947669-86-5 075 exhibits more selective for inhibitingWWL113, CAS No. 947669 86 5, is a novel potent and selective inhibitor of Ces3 and Ces1f with IC50 ~0. 1 M in cellular assays. WWL113 was discovered by a high throughput screen. Carboxylesterase 3 (Ces3, also known as Ces1d) plays a key role in lipid metabolism (e. g., hydrolyzing long chain fatty acid esters and thioesters) and promotes lipid storage in adipocytes. Ces3 activity is markedly elevated during adipocyte differentiation. Treatment of two
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