CCT129202 - CAS# 942947-93-5 10575 18(9):856-61

18(9):856-61

Icosapent is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA)

Formula: C4H10NO5P

a serine/threonine protein kinase overexpressed in certain types of cancer cells

CCT129202 - CAS# 942947-93-5 10575 18(9):856-61CCT129202 is an inhibitor of Aurora kinase activity and displays a favorable antineoplastic effect in preclinical studies. CCT129202 significantly reversed ABCB1 and ABCG2 mediated MDR in vitro, in vivo and ex vivo by inhibiting the function of their transporters and enhanced the eradication of cancer stem like cells by chemotherapeutic agents. CCT129202 may be a candidate as MDR reversal agent for antineoplastic combination therapy and merits further