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ABT-199 - BCL-2 inhibitor. CAS# 1257044-40-8 size:2 mg solid JNK-IN-8 also exhibits exceptional selectivity

ABT-199 - BCL-2 inhibitor. CAS# 1257044-40-8 size:2 mg solid JNK-IN-8 also exhibits exceptional selectivity

Name: ABT-199 - BCL-2 inhibitor. CAS# 1257044-40-8 size:2 mg solid JNK-IN-8 also exhibits exceptional selectivity
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SKU: 92002749274
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SKU: 92002749274

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ABT-199 - BCL-2 inhibitor. CAS# 1257044-40-8 size:2 mg solid JNK-IN-8 also exhibits exceptional selectivityABT 199, CAS No. 1257044 40 8, is a highly potent, selective, and orally bioavailable BCL 2 inhibitor. ABT 199 has picomolar affinity for BCL 2 (Ki < 0. 010 nM) and > 1000 folds selectivity over BCL XL (Ki = 48 nM) and BCL W (Ki = 245 nM). Therefore, ABT 199 is a much improved lead compound over the original ABT 263 (navitoclax) to avoid thrombocytopenia caused by BCL XL inhibition. ABT 199s cell killing effect is selective and mechanism dependent. It

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Description

JNK-IN-8 also exhibits exceptional selectivity based upon KinomeScan and enzymatic profiling

BMC Cancer

Additionally

Smiles: CCCCC1=NC(Cl)=C(C(O)=O)N1CC1C=CC(=CC=1)C1=CC=CC=C1C1NN=NN=1

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