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IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 60276 S3I-201 inhibits breast carcinoma MDA-MB-435

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IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 60276 S3I-201 inhibits breast carcinoma MDA-MB-435IDH C227, CAS No. 1355324 14 9, is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0. 1 M, and 2 HG production in HT1080 and U87MG cells with IC50 < 0. 25 M. Because the mutated form of IDH1 produces the metabolite, 2 hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of

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Description

S3I-201 inhibits breast carcinoma MDA-MB-435

1-diyl))bis(1

4]diazepin-4-yl)-N-ethylacetamide

4]dioxin-6-yl)sulfonyl)-1

IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 60276 S3I-201 inhibits breast carcinoma MDA-MB-435IDH C227, CAS No. 1355324 14 9, is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0. 1 M, and 2 HG production in HT1080 and U87MG cells with IC50 < 0. 25 M. Because the mutated form of IDH1 produces the metabolite, 2 hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of

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