SESN3 Rabbit Polyclonal Antibody, 20ul Endonucleases & Exonucleases Mutations in this gene are

Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS)

The theta class includes GSTT1

The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family

Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect

SESN3 Rabbit Polyclonal Antibody, 20ul Endonucleases & Exonucleases Mutations in this gene areThis gene encodes a member of the sestrin family of stress induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC alpha serine threonine protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript